Melanoma Cell Death Mechanisms

Ironing Out Cell Death Mechanisms

lamin gene (Lmna) develop an EDMD-like syndrome soon after birth and die within 6 weeks of cardiovascular disease. A recent publication by Chen et al. (2012) reports the remarkable finding that downregulation of Sun1 expression in Lmnadeficient mice significantly extended their life span along with amelioration of cardiac pathology. Thus, LINC complexes could represent viable therapeutic target...

Neuronal death and survival - targeting glutamate-induced cell death mechanisms

Mechanisms of cell injury and death.

Control of the rate of cell death relative to the rate of cell division maintains organ integrity and physiological homeostasis. Cell death is valuable for the organism because it removes terminally injured or unwanted cells that utilize valuable substrates and nutrients. Likewise, cell death also has value for the species, as it provides a mechanism for eliminating terminally injured individua...

Mechanisms of cell death in heart disease.

The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a large portion of deaths worldwide. Genetic and pharmacological manipulations indicate that cell death is an important component in the pathogenesis of both diseases. Cells die primarily by apoptosis or necrosis, and autophagy has been associated with cell death. Apoptosis has long been recognized as a hi...

Cell death execution mechanisms in Drosophila

Programmed cell death (PCD) plays a crucial role in neural development as well as in neurodegeneration. To dissect the molecular and genetic pathways of neural cell death, we performed genetic studies using the fruit fly, Drosophila. Our reverse genetic studies showed the significant similarities of cell death execution mechanisms between mammals and Drosophila. A comprehensive search for neura...